research/design-protein 🔢📝 → 🖼️

▶️ 856 runs 📅 Aug 2025 ⚙️ Cog 0.16.2 📄 Paper ⚖️ License
bioinformatics molecular-design protein-design synthetic-biology

About

Design complex Protein de-novo

Example Output

Output

Example output

Performance Metrics

0.04s Prediction Time
42.54s Total Time
All Input Parameters 
{
  "seed": 42,
  "target_length": 49,
  "design_objective": "Design a two-component protein system, consisting of Protein A and Protein B.\nThese two proteins must remain as soluble, stable monomers at a neutral pH of 7.4.\nUpon a decrease in pH to 5.5, they must specifically associate to form a tight heterodimer with a dissociation constant (Kd) in the low nanomolar range.\nThe binding interface should be primarily driven by the protonation of multiple histidine residues, creating favorable electrostatic interactions.\nThe final heterodimeric complex should adopt a rigid, predefined C2 symmetrical architecture.\n"
}
Input Parameters
seed Type: integerDefault: 42
Random seed
target_length Type: integerDefault: 100Range: 10 - 300
Target protein length
design_objective Type: stringDefault: stable protein
Design objective
Output Schema

Output

Type: string • Format: uri

Example Execution Logs 
🧬 Generating protein design...
Length: 49, Objective: Design a two-component protein system, consisting of Protein A and Protein B.
These two proteins must remain as soluble, stable monomers at a neutral pH of 7.4.
Upon a decrease in pH to 5.5, they must specifically associate to form a tight heterodimer with a dissociation constant (Kd) in the low nanomolar range.
The binding interface should be primarily driven by the protonation of multiple histidine residues, creating favorable electrostatic interactions.
The final heterodimeric complex should adopt a rigid, predefined C2 symmetrical architecture.
✅ Design complete! Hydrophobic: 44.9%
Version Details
Version ID
fb3aad06a560284ac65b1c7396728e937b72156833fcac2e5c033422328a6e5c
Version Created
August 8, 2025
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